{"id":277,"date":"2026-08-19T12:56:39","date_gmt":"2026-08-19T12:56:39","guid":{"rendered":"https:\/\/www.peptidelab.co.il\/what-is-mots-c\/"},"modified":"2026-08-23T10:45:32","modified_gmt":"2026-08-23T10:45:32","slug":"what-is-mots-c","status":"publish","type":"post","link":"https:\/\/israelpeptides.co.il\/en\/what-is-mots-c\/","title":{"rendered":"What is MOTS-c? A guide to the mitochondrial peptide"},"content":{"rendered":"<p><strong>MOTS-c<\/strong> is a fascinating peptide that has gained growing interest in research on metabolism and cellular energy. What makes it unique is its source \u2014 the mitochondria. We'll explain.<\/p>\n<p style=\"background:#eef3fa;border-inline-start:3px solid #1f6feb;border-radius:8px;padding:12px 16px;color:#3a4658;font-size:.95em;\">The information in this article is for educational purposes only and does not constitute medical advice. All products on the site are for research use only.<\/p>\n<h2>What is MOTS-c?<\/h2>\n<p>MOTS-c is a \"mitochondrial\" peptide \u2014 meaning its sequence is encoded within the DNA of the mitochondria (the cell's energy centers), and not in the nucleus like most proteins. This is a relatively new group of molecules whose research is still developing.<\/p>\n<h2>What does the research examine?<\/h2>\n<p>Studies have examined MOTS-c in the context of metabolic regulation \u2014 insulin sensitivity, energy balance, and cellular pathways such as AMPK. Some refer to it as a research field of \"mimicking physical activity\" (exercise mimetic), but this is mainly early-stage research.<\/p>\n<h2>Why is it interesting?<\/h2>\n<p>The idea that mitochondria \"broadcast\" molecules that affect the entire body opened a new research direction in the field of metabolism and longevity. That said, most of the data are pre-clinical, and the compound is not approved for use in humans.<\/p>\n<h2>Frequently asked questions<\/h2>\n<p><strong>Is MOTS-c a \"regular\" peptide?<\/strong><br \/>It is a peptide, but unique in that it is encoded in the mitochondria \u2014 which classifies it as a mitochondrial peptide.<\/p>\n<p><strong>How is it reconstituted?<\/strong><br \/>From powder, using <a href=\"\/en\/product\/bac-water\/\">bacteriostatic water<\/a> and<a href=\"\/en\/calculator\/\">our dilution calculator<\/a>.<\/p>\n<p>For the research product details: <a href=\"\/en\/product\/mots-c\/\">MOTS-c<\/a>. For the general guide \u2014 <a href=\"\/en\/peptides-guide\/\">What are peptides<\/a>. More questions in<a href=\"\/en\/faq\/\">Frequently asked questions<\/a>.<\/p>\n<p class=\"pl-buy-cta\">Want to know <a href=\"\/en\/buy-peptides-israel\/\">how to buy peptides in Israel<\/a> right? Our guide explains what to check.<\/p>\n<p><em>The information is general and for educational purposes only and does not constitute medical advice. The products are for research use only.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>MOTS-c \u05d4\u05d5\u05d0 \u05e4\u05e4\u05d8\u05d9\u05d3 \u05de\u05e8\u05ea\u05e7 \u05e9\u05d6\u05db\u05d4 \u05dc\u05e2\u05e0\u05d9\u05d9\u05df \u05d2\u05d5\u05d1\u05e8 \u05d1\u05de\u05d7\u05e7\u05e8 \u05e2\u05dc \u05d7\u05d9\u05dc\u05d5\u05e3 \u05d7\u05d5\u05de\u05e8\u05d9\u05dd \u05d5\u05d0\u05e0\u05e8\u05d2\u05d9\u05d4 \u05ea\u05d0\u05d9\u05ea. \u05de\u05d4 \u05e9\u05de\u05d9\u05d9\u05d7\u05d3 \u05d0\u05d5\u05ea\u05d5 \u05d4\u05d5\u05d0 \u05d4\u05de\u05e7\u05d5\u05e8 \u05e9\u05dc\u05d5 \u2014 \u05d4\u05de\u05d9\u05d8\u05d5\u05db\u05d5\u05e0\u05d3\u05e8\u05d9\u05d4. \u05e0\u05e1\u05d1\u05d9\u05e8. \u05d4\u05de\u05d9\u05d3\u05e2 \u05d1\u05de\u05d0\u05de\u05e8 \u05d4\u05d5\u05d0 \u05dc\u05e6\u05d5\u05e8\u05db\u05d9 \u05dc\u05d9\u05de\u05d5\u05d3 \u05d1\u05dc\u05d1\u05d3 \u05d5\u05d0\u05d9\u05e0\u05d5 \u05de\u05d4\u05d5\u05d5\u05d4 \u05d9\u05d9\u05e2\u05d5\u05e5 \u05e8\u05e4\u05d5\u05d0\u05d9. \u05db\u05dc \u05d4\u05de\u05d5\u05e6\u05e8\u05d9\u05dd \u05d1\u05d0\u05ea\u05e8 \u05de\u05d9\u05d5\u05e2\u05d3\u05d9\u05dd \u05dc\u05de\u05d7\u05e7\u05e8 \u05d1\u05dc\u05d1\u05d3. \u05de\u05d4 \u05d6\u05d4 MOTS-c? MOTS-c \u05d4\u05d5\u05d0 \u05e4\u05e4\u05d8\u05d9\u05d3 &quot;\u05de\u05d9\u05d8\u05d5\u05db\u05d5\u05e0\u05d3\u05e8\u05d9\u05d0\u05dc\u05d9&quot; \u2014 \u05db\u05dc\u05d5\u05de\u05e8 \u05d4\u05e8\u05e6\u05e3 \u05e9\u05dc\u05d5 \u05de\u05e7\u05d5\u05d3\u05d3 \u05d1\u05ea\u05d5\u05da \u05d4-DNA \u05e9\u05dc \u05d4\u05de\u05d9\u05d8\u05d5\u05db\u05d5\u05e0\u05d3\u05e8\u05d9\u05d4 (\u05de\u05e8\u05db\u05d6\u05d9 [&hellip;]<\/p>\n","protected":false},"author":0,"featured_media":299,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_joinchat":[],"footnotes":""},"categories":[40],"tags":[],"class_list":["post-277","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-anti-aging"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/israelpeptides.co.il\/en\/wp-json\/wp\/v2\/posts\/277","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/israelpeptides.co.il\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/israelpeptides.co.il\/en\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/israelpeptides.co.il\/en\/wp-json\/wp\/v2\/comments?post=277"}],"version-history":[{"count":3,"href":"https:\/\/israelpeptides.co.il\/en\/wp-json\/wp\/v2\/posts\/277\/revisions"}],"predecessor-version":[{"id":374,"href":"https:\/\/israelpeptides.co.il\/en\/wp-json\/wp\/v2\/posts\/277\/revisions\/374"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/israelpeptides.co.il\/en\/wp-json\/wp\/v2\/media\/299"}],"wp:attachment":[{"href":"https:\/\/israelpeptides.co.il\/en\/wp-json\/wp\/v2\/media?parent=277"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/israelpeptides.co.il\/en\/wp-json\/wp\/v2\/categories?post=277"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/israelpeptides.co.il\/en\/wp-json\/wp\/v2\/tags?post=277"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}